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KMID : 0829220130370060311
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Korean Journal of Oral and Maxillofacial Pathology
2013 Volume.37 No. 6 p.311 ~ p.321
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mRNA Expression in Porphyromonas Gingivalis-Infected Oral Squamous Cell Carcinoma Cells
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Park Ji-Eun
Woo Vok-Hee
Park Dae-Geun
Park Bong-Soo
Lee Ji-Hye
Pak Hae-Ryoun
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Abstract
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Chronic inflammation is widely considered to predispose individuals to cancer. Microorganisms facilitate recruitment and activation of inflammatory cells and thus allow release of inflammatory mediators. These molecules can then promote accumulation of mutations, leading to tumor development in the host. Porphyromonas gingivalis, a pathogen causing chronic periodontitis, is detected in oral squamous cell carcinoma (OSCC) tissues. Considering a strong link between chronic inflammation and tumor development, functional consequences of P. gingivalis infection may include malignant transformation of the host cells. In this study, we monitored transcriptional changes induced by invasion of P. gingivalis in OSCC cells using microarrays. Our preliminary results suggest changes in a wide range of genes involved in inflammation, apoptosis and autophagy, tumor progression, and carcinogenesis. Further studies on molecular mechanisms underlying these changes will lay a useful foundation to elucidate the role of microorganism-related inflammation and for the development of preventive and therapeutic agents for oral cancer.
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KEYWORD
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Porphyromonas gingivalis, Squamous cell carcinoma, mRNA, Microarray
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